The Top 5 Best Oral Flea & Tick Treatments for Dogs

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If you are not yet using the best oral flea treatments for dogs, your life and your pet’s health and happiness is about to improve. These medications are a terrific flea and tick treatment option to protect your beloved dog(s) from the scratching and potential infections caused by fleas. The following oral flea treatments for dogs reviews and ratings can help you narrow down your search and select the best option for your dog.

The 5 Top Dog Oral Flea Treatments

Editor’s Picks Brand Rating *
Best Choice Capstar Fast-Acting Oral Flea Treatment for Large Dogs ♥♥♥♥♥
Premium Pick Advantus Flea Soft Chews for Large Dogs 23-110lbs ♥♥♥♥♥
Best Value EcoFlea by ColoradoDog Chewable Dog Flea & Tick Treats ♥♥♥♡♡
Runner Up Only Natural Pet EasyDefense Barrier Bites Soft Flea Chews for Dogs ♥♥♥♥♡
Honorable Mention Dog & Cat MD Maximum Defense QuickTabs Nitenpyram Flea Treatment ♥♥♥♥♡
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* Ratings are determined using our specialized rating system.

As part of my volunteering, I help out at an animal rescue. If you think trying to keep fleas off your dog(s) is a challenge, try to protect dozens of them at once. Read on to discover my top picks for the best oral flea treatments for dogs available on the market today.

★ Best Choice
Best Choice for Best Dog Oral Flea Treatment: Capstar Fast-Acting Oral Flea Treatment for Large Dogs

Capstar Fast-Acting Oral Flea Treatment for Large Dogs is the best oral flea treatment for dogs because it works quickly, safely, and effectively, and no prescription is required.

The Capstar Fast-Acting Oral Flea Treatment for Large Dogs comes in a six-pack of tablets containing 57 milligrams each of the medication nitenpyram. One tablet is recommended for a dog that is greater than 25 pounds and weighing up to 125 pounds. This company also offers an additional tablet containing 11 milligrams of nitenpyram, which are recommended for smaller dogs between two pounds and 25 pounds. There is also a version for cats.

If your experience is like mine, you should see a quick, remarkable improvement from this best oral flea treatment for dogs. Fleas start dying off in about thirty minutes. According to the research, up to 90% of adult fleas die within four hours. If your dog has a skin allergy or an irritation from scratching, you can wash them with a non-irritating dog flea and tick shampoo or dog flea and tick medicated spray to remove the dead fleas and help the skin heal. However, it is not recommended using a flea shampoo with a flea medication at the same time.

Pros

  • Nitenpyram is safe for puppies older than four weeks and dogs that weigh at least two pounds
  • Daily use is safe or whenever you see fleas on your pets
  • No prescription required

Cons

  • Nitenpyram does not kill flea eggs
♛ Premium Pick
Premium Pick for Best Dog Oral Flea Treatment: Advantus Flea Soft Chews for Large Dogs 23-110lbs

Advantus Flea Soft Chews for Large Dogs 23-110lbs is the best oral flea treatment for dogs because it is FDA approved, comes in a soft chew form, and is safe for puppies 10 weeks old.

The Advantus Flea Soft Chews for Large Dogs 23-110lbs comes in a bottle of 30 soft chews containing 37.5 milligrams of the active ingredient imidacloprid. This soft chew is not safe for newly born puppies until they are at least ten weeks old. The manufacturer recommends that dogs weigh at least four pounds to use this product. After giving a dog this product, it starts to kill fleas within an hour. The manufacturer claims the research shows it is 96% effective within four hours.

Pros

  • The active ingredient, imidacloprid, is FDA-approved
  • Daily treatment with this product is advisable if fleas persist
  • No prescription is required

Cons

  • Does not kill flea eggs
$ Best Value
Budget Choice for Best Dog Oral Flea Treatment: EcoFlea by ColoradoDog Chewable Dog Flea & Tick Treats

EcoFlea by ColoradoDog All Natural Chewable Dog Treats for Flea and Tick is the best oral flea treatment for dogs because it contains all-natural ingredients, comes in a treat form that is easy to mix with food, and also contains vitamins for added health benefits.

EcoFlea by ColoradoDog All Natural Chewable Dog Treats for Flea and Tick comes as a nine-ounce jar, which contains a 110 to 120 count of chewable dog treats for flea and tick treatment. This product is all-natural and made from the active ingredients of garlic powder, brewer’s yeast, thiamine (B1), vitamin B6, and vitamin B12. Other ingredients include oat flour, bran rice flour, sunflower oil, deionized water, flaxseed meal, vegetable glycerin, sunflower lecithin, guar gum, vitamin C, and blackstrap molasses. For added flavor, it contains organic fruits and vegetables that include cucumbers, lemon, celery, apples, beets, and carrots.

To me, this product sounds more like a delicious health food than a flea treatment. However, the garlic is included so that fleas and ticks do not like the taste of a dog’s blood. The treatment with this product is daily.

Pros

  • All-natural
  • Mixes easily with food
  • Also contains vitamins

Cons

  • Large amounts of garlic is poisonous for dogs and cats
♥ Top Pick
Runner Up for Best Dog Oral Flea Treatment: Only Natural Pet EasyDefense Barrier Bites Soft Flea Chews for Dogs

Only Natural Pet EasyDefense Barrier Bites Soft Flea Chews for Dogs is the best oral flea treatment for dogs because it is a natural supplement that contains vitamins and minerals, plus the manufacturer offers a money-back guarantee.

The Only Natural Pet EasyDefense Barrier Bites Soft Flea Chews for Dogs is a soft-chew treat, which comes in packs of 60 chews or a larger jar of 90 chews. This product is a mineral and vitamin supplement, including Omega 3 and Omega 6 fatty acids, iron, copper, zinc, and the full range of B-complex vitamins. It has garlic powder and brewer’s yeast mixed in that may deter fleas and ticks.

The smell of garlic may be distasteful to fleas and dogs do excrete that garlicky smell after they eat it. However, garlic does not kill fleas. Fleas may jump off the dogs that smell like garlic, but then fleas can live in carpets, jump onto you, and bite you instead.

This product is a decent supplement that contains many nutrients, vitamins, and minerals. If your dogs can tolerate the garlic without getting an upset stomach, it can be useful. Just do not rely too much on the ingredients having a significant impact on fleas. It does not kill them and does nothing at all to kill the flea eggs.

Pros

  • Contains many minerals and vitamins
  • Improve the condition of a dog’s coat
  • Manufacturer offers a 100% guarantee

Cons

  • Large amount of garlic is poisonous for dogs and cats
♥ Top Pick
Honorable Mention for Best Dog Oral Flea Treatment: Dog & Cat MD Maximum Defense QuickTabs Nitenpyram Flea Treatment

Dog & Cat MD Maximum Defense QuickTabs Nitenpyram Flea Treatment is the best oral flea treatment for dogs because they can be given daily to smaller dogs, work effectively in about 30 minutes, and can easily be mixed into food.

The Dog & Cat MD Maximum Defense QuickTabs Nitenpyram Flea Treatment is the correct dosage for dogs or cats that weigh between two and 25 pounds. There are six tablets in a pack with each containing 11.4 milligrams of the active ingredient nitenpyram. This product begins to work in about 30 minutes. About four hours later, it kills up to 90% of all adult fleas. The active ingredient of nitenpyram only kills adult fleas and will not kill flea eggs.

Pros

  • Pills are small enough to mix with food
  • Can be given daily
  • Effective within 30 minutes

Cons

  • To be effective, must be repeated daily

Features to Consider for the Best Dog Oral Flea Treatment

To choose from the oral flea treatment for dogs reviews, research the active ingredients, chat with your vet about safety, learn about the flea life cycle, and do not be fooled by myths.

Active Ingredients

You will want to read and compare the effectiveness of nitenpyram and imidacloprid, which are the two different chemical choices in this category of the best oral flea treatment for dogs.

Flea Egg Cycle

The flea life cycle goes from eggs to larva to pupa to adult fleas, a process that can last from two weeks to many months depending on the environmental conditions. The products I reviewed only kill adult fleas, so treatment must repeat daily for as long as new flea eggs are hatching. Other prescription products last much longer and kill adult fleas, flea eggs, ticks, and other parasites.

One excellent way to use the best oral flea treatment for dogs is in combination with other medications that kill flea eggs. You can use the best oral flea treatment for dogs right away to kill the adult fleas on its body. Then, use a dog flea comb to remove the flea eggs manually.

Benefits of Using Dog Oral Flea Treatments

The biggest benefit when using the best oral flea treatment for dogs—or other flea treatment products such as dog flea dips or dog flea and tick collars—is restful sleep not only for your pet, but for you as well. If you sleep with your pets in your bedroom, even on the floor, and they are scratching all night, it can drive you crazy and result in a lack of restful sleep.

Additionally, the second biggest benefit is no more fleabites. Fleas can bite dogs, cats, other animals, and human adults, children, and babies. If you get a fleabite, it will be a small red dot. It can be itchy and the surrounding skin can be painful. You may even develop a rash, which can potentially progress into an infection or disease.

Fleas are the transmission vectors for diseases because they pass blood from one animal to another animal or humans. With the best oral flea treatment for dogs, you can react fast if you see your dog scratching or if you find fleas.

Precautions of Using Dog Oral Flea Treatments

Garlic is toxic in large amounts, and some products I reviewed contain garlic. About one-third of the people who give garlic to their dogs will find that the dog may have an allergic reaction to the garlic or the dog will have intestinal problems. Therefore, if you give your dog a product with garlic in it, and the dog vomits, seems lethargic, or has diarrhea, you should probably discontinue the use of that product or speak with a vet. Because these products are treats, store them safely.

The other active ingredient in some of these products is nitenpyram or imidacloprid. Adverse side effects are extremely rare, but sometimes they include gastrointestinal reactions, which cause a loss of appetite, vomiting, or diarrhea.

When you give your dogs or cats anything new to ingest, watch them carefully for the next few hours to make sure they do not have a severe negative reaction. If you see extreme symptoms develop, take them to the vet right away.

Conclusion

Our top pick for the best oral flea treatment for dogs review is the Capstar Fast-Acting Oral Flea Treatment for Large Dogs. This heavy dosage of 57 milligrams in each tablet of the active ingredient nitenpyram kills adult fleas. I use this in combination with a product that contains lufenuron, which kills the flea eggs. I love to snuggle with my dogs, so fleas do not stand a chance in my house when using this product.